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Gadd45g and Sex Determination Model
Main components of the transcriptional network around the time of primary sex determination and suggested mechanism of Gadd45g action. In the absence of SRY (XX gonads), female-specific genetic programs (such as the WNT4/beta-catenin pathway) direct differentiation of the somatic support lineage into granulosa cells and ovary development. In XY gonads, SRY expression at 11.5 dpc induces SOX9 expression, Sertoli cell differentiation and testis cord formation. In males, Sertoli cell-derived anti-Müllerian hormone (AMH) induces Müllerian duct regression, and testosterone induces differentiation of the Wolffian duct into vas deferens, seminal vesicles and epididymis. (text from figure legend)
- Links: Testis Development | OMIM - Gadd45g
Reference
Johnen H, González-Silva L, Carramolino L, Flores JM, Torres M & Salvador JM. (2013). Gadd45g is essential for primary sex determination, male fertility and testis development. PLoS ONE , 8, e58751. PMID: 23516551 DOI.
Copyright
© 2013 Johnen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 4. doi:10.1371/journal.pone.0058751.g004 Journal.pone.0058751.g004.jpg
Panel F. cropped from full figure and resized and labeled.
Cite this page: Hill, M.A. (2024, April 27) Embryology Gadd45g and sex determination model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Gadd45g_and_sex_determination_model.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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