File:Folate one-carbon metabolism.jpg

Summary of folate one-carbon metabolism showing the main pathways and reactions that have been subject to analysis in the context of NTDs.

Blue shading: proteins involved in processing of folates in the digestive tract, transport and cellular retention (by addition of glutamates).

Yellow shading: the major part of the cycle involving transfer of 1C groups between folate molecules, as required for purine and pyrimidine biosynthesis.

Pink shading: reactions of the methylation cycle.

For clarity, mitochondrial reactions that include generation of formate and cleavage of glycine have been omitted.

Figure 1. http://hmg.oxfordjournals.org/cgi/content/full/18/R2/R113/DDP347F1

Genetics of human neural tube defects. Greene ND, Stanier P, Copp AJ. Hum Mol Genet. 2009 Oct 15;18(R2):R113-29. Review. PMID: 19808787 | Hum Mol Genet.

© 2009 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

[[Category:Neural]