File:Fetal alcohol syndrome PLGF.jpg

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Fig. 7. Fetal alcohol syndrome PLGF

Diagram summarizing the main effects of in utero alcohol exposure on the placenta and the fetal brain in mouse and human.

a In the placenta, alcohol induced a decrease of PLGF expression in both mouse and human. This effect was associated with a decrease of VEGF-R1 levels in mouse. At a structural level, alcohol consumption altered the density of both villi and vessels in humans. The placental integrity was impacted by a decrease of the placental barrier marker ZO-1 and an increase of the energy metabolism marker MCT-1.

b In the fetal brain, in utero alcohol exposure induced a disorganization of the cortical vasculature. Cortical VEGF-R1 levels were decreased, whereas PLGF was not detected. Recombinant human PLGF administered in the placenta reached the fetal brain. In utero repression of PGF transcription by shRNA mimicked the effects of alcohol on VEGF-R1 in the fetal brain while placental over-expression of the PGF gene induced macromorphic fetuses in the control group and rescued the effects of in utero alcohol exposure on vascular defects in the fetal brain. In human, vascular brain defects correlated with vascular placental defects.m,h indicate the experiments performed in mouse and/or human; WB, Western blot approach; IHC, immunohistochemistry


Links: Fetal Alcohol Syndrome

Reference

Lecuyer M, Laquerrière A, Bekri S, Lesueur C, Ramdani Y, Jégou S, Uguen A, Marcorelles P, Marret S & Gonzalez BJ. (2017). PLGF, a placental marker of fetal brain defects after in utero alcohol exposure. Acta Neuropathol Commun , 5, 44. PMID: 28587682 DOI.

Copyright

© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.


Cite this page: Hill, M.A. (2024, April 18) Embryology Fetal alcohol syndrome PLGF.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Fetal_alcohol_syndrome_PLGF.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current10:21, 19 June 2017Thumbnail for version as of 10:21, 19 June 20171,096 × 1,500 (245 KB)Z8600021 (talk | contribs)
10:21, 19 June 2017Thumbnail for version as of 10:21, 19 June 20172,013 × 2,092 (502 KB)Z8600021 (talk | contribs)==Fig. 7. Fetal alcohol syndrome PLGF== Diagram summarizing the main effects of in utero alcohol exposure on the placenta and the fetal brain in mouse and human. a In the placenta, alcohol induced a decrease of PLGF expression in both mouse and huma...

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