File:Fetal adrenal gland steroidogenesis.jpg

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Fetal Adrenal Gland Steroidogenesis

Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).

Fetal zone (FZ) - expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.

Second trimester - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).

Third trimester - the newly constituted transitional zone (TZ, medium grey) acquires the enzyme 3ß-HSD while the expression of P450C17 remains, thus allowing the production of fetal cortisol. Near birth, cells of the definitive zone which express only 3ß-HSD, acquire the P450aldo and begin to secrete mineralocorticoids such as aldosterone.

Neonatal - the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life.

Adult - adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.

  • P450scc - cytochrome P450 side chain cleavage
  • Pregn. - pregnenolone
  • P450C17 - cytochrome P450 17a-hydroxylase, 17-20 lyase
  • 17OHP5 - 17-hydroxy-pregnenolone
  • DHEA/S - dehydroepiandrosterone-sulfate
  • S-Tfase - DHEA sulfotransferase
  • 3ß-HSD - 3ß-hydroxysteroid dehydrogenase
  • Prog. - progesterone
  • 17OHP4 - 17-hydroxyprogesterone
  • P450C21 - cytochrome P450 21-hydroxylase
  • P450C11 - cytochrome P450 11ß-hydroxylase
  • P450aldo - cytochrome P450 aldosterone synthase.
Links: Adrenal Development

Reference

Chamoux E, Otis M & Gallo-Payet N. (2005). A connection between extracellular matrix and hormonal signals during the development of the human fetal adrenal gland. Braz. J. Med. Biol. Res. , 38, 1495-503. PMID: 16172742 DOI.

Some Data - Mesiano S & Jaffe RB. (1997). Developmental and functional biology of the primate fetal adrenal cortex. Endocr. Rev. , 18, 378-403. PMID: 9183569 DOI.

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Cite this page: Hill, M.A. (2024, April 25) Embryology Fetal adrenal gland steroidogenesis.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Fetal_adrenal_gland_steroidogenesis.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current08:33, 11 November 2015Thumbnail for version as of 08:33, 11 November 2015778 × 600 (80 KB)Z8600021 (talk | contribs)
08:24, 11 November 2015Thumbnail for version as of 08:24, 11 November 2015778 × 600 (71 KB)Z8600021 (talk | contribs)Figure 1. Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrena...