File:Female reproductive tract Wnt4.jpg

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Processes regulated by Wnt4 during female reproductive tract development

Wnt4 is required during prenatal and postnatal development of female reproductive tract. The initial MD primordium occurs independently of Wnt4 function (E11.5, the MD primordium in red). After initiation of the process, differentiation of the MD tip cells, prenatal elongation of the MD and postnatal formation of the endometrial gland (eG) all depend on Wnt4 signalling.

The daughter cells that are initially Wnt4+ contribute to MD and eG formation.

Myo, myometrium; E, endometrium; eG, endometrial glands; L, lumen.

Links: Vagina Development | Uterus Development


Prunskaite-Hyyryläinen R, Skovorodkin I, Xu Q, Miinalainen I, Shan J & Vainio SJ. (2016). Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract. Hum. Mol. Genet. , 25, 1059-73. PMID: 26721931 DOI.


Prunskaite-Hyyryläinen, Renata; Skovorodkin, Ilya

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Cite this page: Hill, M.A. (2024, April 12) Embryology Female reproductive tract Wnt4.jpg. Retrieved from

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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