File:Female genital tract chlamydia trachomatis infection 02.jpg
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Female Genital Tract - Chlamydia trachomatis developmental cycle
Chlamydia trachomatis is an obligate intracellular pathogen that resides within a specialized vacuole and has a biphasic developmental cycle.
An infectious, but metabolically inactive, elementary body (EB) is taken up by mucosal epithelial cells. After internalization, the EB is surrounded by an endosomal membrane to form an inclusion — a vacuole formed from normal endosomal-trafficking pathways — which creates a permissive intracellular niche for the replication of C. trachomatis. Within the inclusion, the EB transforms into a larger metabolically active reticulate body (RB), which divides by binary fission. Within 40–48 hours (hr), the RBs transform back into infective EBs, which are subsequently released from the inclusion vacuole to infect neighbouring cells. In the presence of growth inhibitors, such as interferon-gamma, intracellular C. trachomatis bacteria acquire a non-replicating, persistent form, and bacteria in this form differentiate back into infectious forms after removal of the inhibitor.
- EB - elementary body
- RB - reticulate body
- Links: Image - chlamydia trachomatis infection | Image - chlamydia trachomatis cycle | Bacterial Infection | Ectopic Implantation
Reference
<pubmed>15688042</pubmed>| Nat Rev Immunol.
Copyright
Reprinted by permission from Macmillan Publishers Ltd: Nature Reviews Immunology <pubmed>15688042</pubmed>, copyright (2005).
Nri1551-f2.jpg text original figure legend.
Cite this page: Hill, M.A. (2024, April 27) Embryology Female genital tract chlamydia trachomatis infection 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Female_genital_tract_chlamydia_trachomatis_infection_02.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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| current | 14:40, 3 September 2014 | | 707 × 550 (60 KB) | Z8600021 (talk | contribs) | ==Female Genital Tract - Chlamydia trachomatis developmental cycle== Chlamydia trachomatis is an obligate intracellular pathogen that resides within a specialized vacuole and has a biphasic developmental cycle. An infectious, but metabolically inacti... |
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