File:Epidermis cartoon 01.jpg

From Embryology

Epidermis_cartoon_01.jpg(545 × 375 pixels, file size: 96 KB, MIME type: image/jpeg)

General structure of the Adult Epidermis

This cartoon shows keratinocyte differentiation (cornification) within overall structure of the skin epithelium. In addition, the cellular junctions are also indicated.

  1. stratum basale - (basal layer) keratinocytes proliferate by mitosis. This layer also contains the stem cell population.
  2. stratum spinosum - keratinocytes reinforce their cytoskeletal keratin filament network and adjacent cells interact through desmosomes.
  3. stratum granulosum - keratinocytes become more flattened and express proteins that aggregate to form keratohyalin granules. Lipids are also produced and stored in lamellar bodies.
  4. stratum corneum - keratinocytes lose their organelles, including the nucleus, and become the dead, flattened corneocytes.

Links: Integumentary System Development



J Cell Biol. 2008 February 11; 180(3): 451–458. doi: 10.1083/jcb.200709098.

Copyright © 2008, The Rockefeller University Press


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current14:30, 17 May 2012Thumbnail for version as of 14:30, 17 May 2012545 × 375 (96 KB)Z8600021 (talk | contribs)==General structure of the Adult Epidermis== Introduction excerpt: :"The basal layer, or stratum basale, of the epidermis contains proliferating keratinocytes (Fig. 1). Upon withdrawal from the cell cycle, these basal keratinocytes detach from the basem

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