File:Desmosome 02.jpg

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Epithelial Junctions Electron Micrograph

Junctional complex between two cells in the epithelium of the intestinal mucosa (rat), intestinal lumen is towards the top of image.

The limits of a desmosome are marked by arrows 4 and 5. This element is characterized by a wide intercellular space (~240 A) bisected by an intermediate line (id). Bundles of cytoplasmic fibrils (fd), coarser (diameter ~80 A) and more distinct than those of the terminal web, converge into dense plates (pd) on each side of the desmo- some. These plates are separated from the inner leaflets of the cell membrane by a zone of low density. Similar fibrils (if) appear throughout the remainder of the field below the terminal web.

Between the intermediate junction and the desmosome, the two apposed cell membranes are separated by an irregular space of varying width and show membrane invaginations and associated vesicles (v). The trilaminar structure of the cell membrane (cm) shows clearly along the mlcrovilli (my), (wherever the membrane is sectioned normally), and within the desmosome. It can also be made out, though less regularly, along the lateral cell margins (e.g., at unnumbered arrow). Note that the luminal membrane is nearly symmetrical, the outer leaflet being only slightly thinner and less dense than the inner leaflet, whereas the lateral membrane is definitely asymmetrical. The total thickness of all three layers is about 110 A along the apical surface of the cell but measures only about 70 to 80 A along the lateral intercellular spaces. Note also the fluffy dense material (fro) (probably mucus) associated with the tips and sides of the microvilli.

Specimen fixed in 2 per cent OsO4 in acetate-Veronal buffer (pH 7.6) ; and embedded in Epon. Pb(OH)2-stained section. X 96,000. (Stain - Osmium)

(text from original figure legend)

A = angstrom or ångström 1×10−10 m

Adhesion EM Images: GIT epithelia EM1 | GIT epithelia EM2 | GIT epithelia EM3 | Desmosome EM
Adhesion Cartoons: Tight junction | Adherens Junction | Desmosome | Gap Junction


FARQUHAR MG & PALADE GE. (1963). Junctional complexes in various epithelia. J. Cell Biol. , 17, 375-412. PMID: 13944428



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current12:33, 3 March 2012Thumbnail for version as of 12:33, 3 March 2012600 × 450 (74 KB)Z8600021 (talk | contribs)==Epithelial Junctions Electron Micrograph== Junctional complex between two cells in the epithelium of the intestinal mucosa (rat), intestinal lumen is towards the top of image. The tight junction (zonula occludens), located nearest the lumen, extends f