File:Canonical and non-canonical signalling TGF beta pathways.png

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Canonical and non-canonical signalling TGF beta pathways[1]

Image Title

SMAD proteins are signal transducers and transcriptional modulators that mediate the signal of the TGF-β pathway. It is enlisted to the TGF-β receptors through its communication with the SMAD anchor for receptor activation (SARA) protein, then phosphorylated by the TGF-β receptors as a response to TGF-β signal. The phosphorylation activates the disjunction of this protein with SARA and the connection with the family member SMAD4. The link with SMAD4 is significant for when the protein moves into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.

Growth factor receptor-bound proteins (GRB) are required in signal transduction/cell communication.

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Mark Hill (talk) 16:25, 1 November 2016 (AEDT) This is the correct copyright statement - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.

Note - This image was originally uploaded as part of an undergraduate science student project and may contain inaccuracies in either description or acknowledgements. Students have been advised in writing concerning the reuse of content and may accidentally have misunderstood the original terms of use. If image reuse on this non-commercial educational site infringes your existing copyright, please contact the site editor for immediate removal.
  1. Neuzillet C, de Gramont A, Tijeras-Raballand A, de Mestier L, Cros J, Faivre S & Raymond E. (2014). Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas. Oncotarget , 5, 78-94. PMID: 24393789 DOI.

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current01:12, 20 October 2016Thumbnail for version as of 01:12, 20 October 2016546 × 419 (254 KB)Z5019526 (talk | contribs)

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