File:Bronchial epithelial bridge.jpg

Bronchial epithelial (EP) bridge brings EP islands together over time

Using various cellular imaging techniques on human tissue cultures, we identified two types of tubular, bronchial epithelial (EP) connections, up to a millimeter in length, designated EP bridges

Two EP islands connected by an EP bridge migrated towards each other, which reduced EP bridge length until the EP bridge disappeared as the two EP islands became one EP island in EPs/ECs over 7 h. Each frame was taken using a Nikon Diaphot inverted microscope with a 10x phase lens.

Time point for each frame is specified in the video. Scale bars: 50 µm.

(0.76 MB MOV)

--Mark Hill 12:32, 14 April 2011 (EST) A similar mechanism has recently been identified for neural crest communication during development. <pubmed>21472890</pubmed>

Original File name: Movie Link - Journal.pone.0008930.s013.mov

Reference

Citation: Zani BG, Indolfi L, Edelman ER (2010) Tubular Bridges for Bronchial Epithelial Cell Migration and Communication. PLoS ONE 5(1): e8930. doi:10.1371/journal.pone.0008930

Editor: Rory Edward Morty, University of Giessen Lung Center, Germany

Received: October 20, 2009; Accepted: January 11, 2010; Published: January 28, 2010

Copyright: © 2010 Zani et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.