File:Branchial arch muscle cartoon.jpg
Branchial_arch_muscle_cartoon.jpg (454 × 381 pixels, file size: 40 KB, MIME type: image/jpeg)
Molecular signaling model of Pitx2 roles in the first branchial arch (BA) muscle development.
Pitx2 is expressed in the oral ectoderm and first and second branchial arch (BA). Pitx2 was expressed before the myogenic onset in the first branchial arch mesodermal core and was required for the first branchial arch muscle specification by modulating premyoblast specification markers, such as Tbx1, Tcf21, and Msc in early stages.
These transcription factors are required for the Myf5 and MyoD activation in the first branchial arch muscle precursors. Pitx2 may also directly control the expression of MRFs and regulate the differentiation of the muscle in later stages. Pitx2 was not required for the second BA specification.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1851590&tool=pmcentrez
Zpq0120757200004.jpg
Proc Natl Acad Sci U S A. 2007 April 3; 104(14): 5907–5912. Published online 2007 March 23. doi: 10.1073/pnas.0701122104.
Copyright © 2007 by The National Academy of Sciences of the USA
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| current | 11:54, 29 August 2009 | | 454 × 381 (40 KB) | S8600021 (talk | contribs) | Model of Pitx2 roles in the first branchial arch (BA) muscle development. Pitx2 is expressed in the oral ectoderm and first and second branchial arch (BA). Pitx2 was expressed before the myogenic onset in the first branchial arch mesodermal core and was |
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