File:Anderson2016-fig42a.jpg

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Fig. 42a. Mouse E11.5 Heart Arterial roots within the intermediate component of the outflow tract

The images show the stages involved in formation of the arterial roots within the intermediate component of the outflow tract.

The left hand panel is a cross-section through the intermediate component at the end of E11.5. The central parts of the distal cushions have fused, but the parietal parts remain unfused. Together with the formation of the intercalated cushions, this sets the scene for formation of the leaflets of the arterial valves. This occurs during E12.5 and E13.5 by excavation of the distal ends of the cushions, as shown in the right hand panel for the pulmonary valve.

At this relatively early stage, there has been minimal ingrowth of non-myocardial tissue to form the valvar sinuses, so that the distal myocardial border still remains adjacent to the tips of the developing valvar leaflets (white arrows with black borders). The sinuses continue to form subsequent to E13.5, which is the stage, in the mouse, of closure of the embryonic interventricular communication, equivalent to CS23, or eight weeks of development, in the human.


Figure Links: 1 Heart tube mouse E8 | 2 Ventricular loop mouse E8 | 3 Heart mouse E10.5 | 4 Atrial component mouse E10.5 | 5 Sinus horns mouse E8.5 | 6 Venous valve mouse E10.5 | 7a Left atrium CS14 | 7b Atrioventricular canal CS14 | 8a Atrioventricular canal mouse E10.5 | 8b Outflow tract mouse E10.5 | 9a Atrioventricular canal CS14 | 9b Right ventricle CS14 | 10 Ventricular septal defect | fig 11a | fig 11b | fig 12a | fig 12b | fig 13a | fig 13b | fig 14 | fig 15a | fig 15b | fig 16a | fig 16b | fig 17a | fig 17b | fig 18 | fig 19 | fig 20 | fig 21 | fig 22 | fig 23 | fig 24a | fig 24b | fig 25a | fig 25b |fig 26a | fig 26b | fig 27a | fig 27b | fig 28a | fig 28b | fig 29a | fig 29b | fig 30 | fig 31 | fig 32a | fig 32b | fig 33a | fig 33b | fig 34a | fig 34b | fig 35a | fig 35b | fig 36 | fig 37 | fig 38 | fig 39a | fig 39b | fig 40a | fig 40b | fig 41a | fig 41b | fig 42a | 42b | 43a Stenotic pulmonary valve | 43b Stenotic aortic valve | fig 44a | fig 44b | fig 45a | fig 45b | fig 46a | fig 46b | fig 47 | fig 48 | fig 49 | fig 50a | fig 50b | Figure Gallery

Reference

Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)


Cite this page: Hill, M.A. (2024, April 13) Embryology Anderson2016-fig42a.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Anderson2016-fig42a.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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