File:Anderson2016-fig29b.jpg

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Fig. 29b. Mouse E18.5 Heart Atrioventricular Septal Defect

The images are from a mouse embryo at E18.5 with an “ostium primum” atrioventricular septal defect.

The short axis cut from the same heart, right hand panel as seen from the ventricular aspect, reveals that the superior and inferior atrioventricular cushions have fused not only with the ventricular septum, but also with each other (white dotted line). The left atrioventricular valve now has three leaflets, retaining the initial figuration of the undivided atrioventricular canal (see Figure 25 – left hand panel). The aortic root is committed to the left ventricle, but is no longer wedged between the left atrioventricular valvar orifice and the muscular ventricular septum (compare with Figure 27 – right hand panel).


The left hand panel shows a four chamber cut, revealing the persisting primary atrial foramen, with a common atrioventricular junction (double headed white arrow), but with shunting possible only at atrial level because the inferior atrioventricular cushion is firmly fused to the crest of the muscular ventricular septum. The mesenchymal cap has muscularised to form the leading margin of the oval fossa, but there has been no growth of the vestibular spine.


Figure Links: 1 Heart tube mouse E8 | 2 Ventricular loop mouse E8 | 3 Heart mouse E10.5 | 4 Atrial component mouse E10.5 | 5 Sinus horns mouse E8.5 | 6 Venous valve mouse E10.5 | 7a Left atrium CS14 | 7b Atrioventricular canal CS14 | 8a Atrioventricular canal mouse E10.5 | 8b Outflow tract mouse E10.5 | 9a Atrioventricular canal CS14 | 9b Right ventricle CS14 | 10 Ventricular septal defect | fig 11a | fig 11b | fig 12a | fig 12b | fig 13a | fig 13b | fig 14 | fig 15a | fig 15b | fig 16a | fig 16b | fig 17a | fig 17b | fig 18 | fig 19 | fig 20 | fig 21 | fig 22 | fig 23 | fig 24a | fig 24b | fig 25a | fig 25b |fig 26a | fig 26b | fig 27a | fig 27b | fig 28a | fig 28b | fig 29a | fig 29b | fig 30 | fig 31 | fig 32a | fig 32b | fig 33a | fig 33b | fig 34a | fig 34b | fig 35a | fig 35b | fig 36 | fig 37 | fig 38 | fig 39a | fig 39b | fig 40a | fig 40b | fig 41a | fig 41b | fig 42a | 42b | 43a Stenotic pulmonary valve | 43b Stenotic aortic valve | fig 44a | fig 44b | fig 45a | fig 45b | fig 46a | fig 46b | fig 47 | fig 48 | fig 49 | fig 50a | fig 50b | Figure Gallery

Reference

Anderson RH. Teratogenecity in the setting of cardiac development and maldevelopment. (2016)


Cite this page: Hill, M.A. (2024, April 25) Embryology Anderson2016-fig29b.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Anderson2016-fig29b.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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