File:Adult human liver cells.jpg

Adult Human Liver Cells

Summary map of the human liver. The main “building block” of the liver is the hepatic lobule, which includes a portal triad, hepatocytess aligned between a capillary network, and a central vein.

The portal triad is made up of the hepatic artery, the portal vein and the bile duct. Found between the liver sinusoids are parenchymal cells (hepatocytess) and non-parenchymal cells (endothelial cells, cholangiocytes, macrophages, hepatic stellate cells, and liver infiltrating lymphocytes- including B cells, αβ and γδ, T cells, and NK cells).

Non-inflammatory macrophages are labeled ∗Kupffer cells based on their transcriptional similarity to mouse KC. The location of B cells, plasma cells, T cells, and NK cells has yet to be confirmed by immunohistochemical staining of these populations in situ so their location in this schematic is not representative of their zonated distribution. The zonation of hepatocytes was not confirmed by immunohistochemical staining and is inferred as a result of pathway analysis and transcriptional similarity to the zonated gene expression patterns previously shown in mice.

Links: liver

Reference

Aizarani N, Saviano A, Sagar L, Mailly S, Durand JS, Herman P, Pessaux TF, Baumert D & Grün. (2019). A human liver cell atlas reveals heterogeneity and epithelial progenitors. Nature , , . PMID: 31292543 DOI.

Nature. 2019 Jul 10. doi: 10.1038/s41586-019-1373-2. [Epub ahead of print] A human liver cell atlas reveals heterogeneity and epithelial progenitors.

Copyright

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

Cite this page: Hill, M.A. (2024, April 27) Embryology Adult human liver cells.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Adult_human_liver_cells.jpg

What Links Here?

© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G