File:Adrenal and gonad steroidogenic factor 1 expression.jpg
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Adrenal and Gonad Steroidogenic Factor 1 Expression
The key events of steroidogenic tissues development in mice are shown. Molecular players in male sex (SRY, SOX9, SF-1, Dax-1) and female sex determination (Wnt4, Dax-1) are shown. Dax-1 function in sex determination is still unclear.
Steroidogenic factor 1 (SF-1) levels of expression are schematically presented below the time scale.
Abbreviations
- E - embryonic day
- dpc - days post coïtum
- dpp - days post partum
- dpo - days post ovulation
Steroidogenic Factor 1
- 53 kDa protein called Ad4BP (Adrenal 4 Binding Protein) or SF-1 (Steroidogenic Factor 1)
- classical DNA-binding domain (DBD) characterized by two Cys2-Cys2 zinc fingers in the N-terminal region
- SF-1 binds DNA as a monomer
- high homology with the drosophila Ftz-F1 transcription factor that controls fushi tarazu homeotic gene expression
Reference
Val P, Lefrançois-Martinez AM, Veyssière G & Martinez A. (2003). SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl. Recept. , 1, 8. PMID: 14594453 DOI.
Copyright
© 2003 Val et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Original file name: Figure 2. 1478-1336-1-8-2-l.jpg http://www.nuclear-receptor.com/content/1/1/8/figure/F2
Cite this page: Hill, M.A. (2024, April 27) Embryology Adrenal and gonad steroidogenic factor 1 expression.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Adrenal_and_gonad_steroidogenic_factor_1_expression.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
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