File:Adrenal and gonad steroidogenic factor 1 expression.jpg

From Embryology

Original file(1,000 × 636 pixels, file size: 88 KB, MIME type: image/jpeg)

Adrenal and Gonad Steroidogenic Factor 1 Expression

The key events of steroidogenic tissues development in mice are shown. Molecular players in male sex (SRY, SOX9, SF-1, Dax-1) and female sex determination (Wnt4, Dax-1) are shown. Dax-1 function in sex determination is still unclear.

Steroidogenic factor 1 (SF-1) levels of expression are schematically presented below the time scale.

Abbreviations

  • E - embryonic day
  • dpc - days post coïtum
  • dpp - days post partum
  • dpo - days post ovulation

Steroidogenic Factor 1

  • 53 kDa protein called Ad4BP (Adrenal 4 Binding Protein) or SF-1 (Steroidogenic Factor 1)
  • classical DNA-binding domain (DBD) characterized by two Cys2-Cys2 zinc fingers in the N-terminal region
  • SF-1 binds DNA as a monomer
  • high homology with the drosophila Ftz-F1 transcription factor that controls fushi tarazu homeotic gene expression

Reference

Val P, Lefrançois-Martinez AM, Veyssière G & Martinez A. (2003). SF-1 a key player in the development and differentiation of steroidogenic tissues. Nucl. Recept. , 1, 8. PMID: 14594453 DOI.


Copyright

© 2003 Val et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

Original file name: Figure 2. 1478-1336-1-8-2-l.jpg http://www.nuclear-receptor.com/content/1/1/8/figure/F2


Cite this page: Hill, M.A. (2024, April 20) Embryology Adrenal and gonad steroidogenic factor 1 expression.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Adrenal_and_gonad_steroidogenic_factor_1_expression.jpg

What Links Here?
© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current12:45, 3 November 2010Thumbnail for version as of 12:45, 3 November 20101,000 × 636 (88 KB)S8600021 (talk | contribs)==Adrenal and Gonad Steroidogenic Factor 1 Expression== The key events of steroidogenic tissues development in mice are shown. Molecular players in male sex (SRY, SOX9, SF-1, Dax-1) and female sex determination (Wnt4, Dax-1) are shown. Dax-1 function in

The following 2 pages use this file: