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Adipocyte Differentiation Regulation

Zfp521 is novel modulator of adipocyte commitment and differentiation.

Many transcription factors are induced during adipocyte differentiation. Some of these, like members of the AP-1 family, are induced early during adipocyte development. Other transcription factors like PPARγ promote adipocyte differentiation. Adipocyte development is also influenced by several transcription factor families that have negative effectors on adipogenesis. Zfp521 is a novel modulator of adipocyte development that mediates its inhibitory effects on adipocyte development by regulating the activity of two other transcription factors, Zfp423 and Ebf1.


Reference

Stephens JM. (2012). The fat controller: adipocyte development. PLoS Biol. , 10, e1001436. PMID: 23209380 DOI.

Copyright

© 2012 Jacqueline M. Stephens. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 1. Journal.pbio.1001436.g001.jpg doi:10.1371/journal.pbio.1001436.g001


Cite this page: Hill, M.A. (2024, April 13) Embryology Adipocyte differentiation regulation 01.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Adipocyte_differentiation_regulation_01.jpg

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© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G

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current19:34, 18 February 2013Thumbnail for version as of 19:34, 18 February 20131,000 × 704 (90 KB)Z8600021 (talk | contribs)==Adipocyte Differentiation Regulation== Zfp521 is novel modulator of adipocyte commitment and differentiation. Many transcription factors are induced during adipocyte differentiation. Some of these, like members of the AP-1 family, are induced early du

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