File:Preconceptional folate and risk preterm birth.png

Cumulative risk of spontaneous preterm birth in relation to duration of preconceptional folate supplementation.

Folate = 0*, no preconceptional folate supplementation.

Folate <1 yr*, preconceptional folate supplementation for less than a year.

Folate > = 1 yr*, preconceptional folate supplementation for a year or longer.

• Test for trend of survivor functions, p = 0.01.

Figure 1. Journal.pmed.1000061.g001.png

http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1000061

Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. Bukowski R, Malone FD, Porter FT, Nyberg DA, Comstock CH, Hankins GD, Eddleman K, Gross SJ, Dugoff L, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, D'Alton ME. PLoS Med. 2009 May 5;6(5):e1000061. Epub 2009 May 12. PMID: 19434228

Reference

Bukowski R, Malone FD, Porter FT, Nyberg DA, Comstock CH, et al. (2009) Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study. PLoS Med 6(5): e1000061. doi:10.1371/journal.pmed.1000061

Editor: Nicholas M. Fisk, University of Queensland Centre for Clinical Research, Australia

Received: September 8, 2008; Accepted: March 3, 2009; Published: May 12, 2009

Copyright

© 2009 Bukowski et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.