File:Developmental gene expression context model.jpg

Developmental Gene Expression Model

A model of three hypothetical genes (yellow, red and green) and their hypothetical expression pattern at a given stage of embryonic development are shown. Embryos coloured blue show the activity of a given reporter gene integrated at different chromosomal locations (adapted from ref. 16). They illustrate that genomic context critically determines expression patterns.

a, various insertion sites may display comparable expression patterns despite being spread over a large chromosomal interval. Note that these reporter genes incorporate most of the regulatory activities acting on the downstream gene shown in yellow.

b, Often, the reporter gene incorporates the enhancer activities that control the expression of one the nearest genes (red gene).

c, Tissue-specific reporter gene expression can sometimes be seen at sites close to housekeeping genes (green gene). In addition, two closely linked integration sites may show very distinct expression patterns that reveal highly localized regulatory circuits.

d, At some chromosomal sites, the reporter gene is inactive and apparently not capable of capturing enhancer activity.

Reference

<pubmed>24153303</pubmed>| Nature

Copyright

Reprinted by permission from Macmillan Publishers Ltd: NATURE (Nature. 2013 Oct 24;502(7472):499-506. doi: 10.1038/nature12753), copyright (2013)

http://www.nature.com/nature/journal/v502/n7472/fig_tab/nature12753_F2.html Nature12753-f2.jpg

Cite this page: Hill, M.A. (2024, June 3) Embryology Developmental gene expression context model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Developmental_gene_expression_context_model.jpg

What Links Here?

© Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G