Cardiac Muscle Histology
Cardiac muscle, the myocardium, consists of cross-striated muscle cells, cardiomyocytes, with one centrally placed nucleus.
- Nuclei are oval, rather pale and located centrally in the muscle cell which is 10 - 15 µm wide.
- Cardiac muscle cells excitation is mediated by rythmically active modified cardiac muscle cells.
- Cardiac muscle is innervated by the autonomic nervous system (involuntary), which adjusts the force generated by the muscle cells and the frequency of the heart beat.
- Cardiac muscle cells often branch at acute angles and are connected to each other by specialisations of the cell membrane in the region of the intercalated discs.
- Intercalated discs invariably occur at the ends of cardiac muscle cells in a region corresponding to the Z-line of the myofibrils.
- Cardiac muscle does not contain cells equivalent to the satellite cells of skeletal muscle.
- Inner layer of the heart, contains blood vessels. Has 3 sublayers
- Endothelium - innermost portion a simple squamous epithelium.
- Smooth Muscle and Connective Tissue - middle layer of the endocardium is mix of connective tissue and smooth muscle.
- Subendocardial Layer - outer layer of the endocardium is loose connective tissue joining the endocardium and myocardium.
- Middle layer of the heart, thickest contains cardiomyocytes, blood vessels.
- Muscular layer.
- Outer layer of the heart, contains blood vessels and lymphatics.
- Visceral layer of pericardium rather thin.
- seen in longitudinal sections.
- connect the individual muscle cells.
- permit the conduction of electrical impulses between the cells.
Histology "step-like" appearance due to:
- transverse part - crossing fibres at right angle to myofibrils.
- lateral part - runs in parallel to myofibrils.
- Fascia adherens – major portion of transverse component. Anchoring sites for actin, and connect to the closest sarcomere.
- Macula adherens – (desmosomes) transverse and lateral components. Bind individual myocytes to one another. stop separation during contraction by binding intermediate filaments, joining the cells together. Macula adherens junctions are also called desmosomes.
- Gap junctions - lateral component. Allow action potentials to spread between cardiac cells by passage of ions between cells, producing depolarization of the heart muscle. Allows muscle to act as syncytium.
- Links: EM image - intercalated disc
- modified cardiac muscle cells. Compared to ordinary cardiac muscle cells:
- contain large amounts of glycogen.
- fewer myofibrils.
- thicker cells.
- extend from the atrioventricular node, pierces the fibrous body, divides into left and right bundles, and travels, beneath the endocardium, towards the apex of the heart.
- bundle branches contact cardiac muscle cells through specialisations similar to intercalated discs.
- conduct stimuli faster than ordinary cardiac muscle cells (2-3 m/s vs. 0.6 m/s).
- discovered in 1839 by Jan Evangelista Purkyně).
- Links: Heart Histology | Cardiac AZB Labeled | Cardiac AZB | Cardiac label LS | Cardiac LS | Cardiac label TS | Cardiac TS | Purkinje fibres | Purkinje fibres detail | Histology
- cardiomyocyte -
- chordae tendineae - tricuspid and mitral valves connective tissue bands attached on the other end to the papillary muscles.
- intercalated disc -
- nodule - (of semilunar valve) small fibrous nodules located in the middle of the flaps, the nodules of the semilunar valve come closely together to fill the triangular opening.
- Purkinje fibres -
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Cite this page: Hill, M.A. (2019, December 15) Embryology Cardiac Muscle Histology. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Cardiac_Muscle_Histology
- © Dr Mark Hill 2019, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G