Bone Development: Difference between revisions
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== Introduction == | == Introduction == | ||
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===Slides=== | ===Slides=== | ||
* UNSW Virtual Slidebox [http://web.med.unsw.edu.au/vslide/phase1/indexA1.asp Virtual Slidebox Phase 1] | |||
# Compact Bone - Adult [http://vslide2.med.unsw.edu.au/slide.jsp?fn=anatomy/ANAT6777.svs&mag=40 Bone , Adult (Ground, TS) Human Alizarin Red] | [http://vslide2.med.unsw.edu.au/slide.jsp?fn=anatomy/ANAT6846.svs&mag=40 Bone (Ground, LS) Human Alizarin Red] | |||
# Compact Bone Rib [http://vslide2.med.unsw.edu.au/slide.jsp?fn=histology/b10_40xr.fpx&mag=40 Decalcified rib, bone marrow] | |||
# Endochondral ossification [http://vslide2.med.unsw.edu.au/slide.jsp?fn=histology/b12_40xr.fpx&mag=40 Developing bone] | [http://vslide2.med.unsw.edu.au/slide.jsp?fn=anatomy/ANAT6778.svs&mag=40 Bone, Developing (LS, Femur) Cat H&E] | |||
# Intramembranous ossification [http://vslide2.med.unsw.edu.au/slide.jsp?fn=anatomy/ANAT893.svs&mag=40&mag=40 Head (Neonatal) Rat H& Van Gieson] | |||
===Haversian Systems=== | ===Haversian Systems=== | ||
Revision as of 11:11, 21 September 2009
Introduction
Textbook
Histology and Cell Biology: An Introduction to Pathology, A.L. Kierszenbaum, 2002 - Connective Tissue, Chapter 4 pp118-129; Osteogenesis, Chapter 5 pp131-145
Slides
- UNSW Virtual Slidebox Virtual Slidebox Phase 1
- Compact Bone - Adult Bone , Adult (Ground, TS) Human Alizarin Red | Bone (Ground, LS) Human Alizarin Red
- Compact Bone Rib Decalcified rib, bone marrow
- Endochondral ossification Developing bone | Bone, Developing (LS, Femur) Cat H&E
- Intramembranous ossification Head (Neonatal) Rat H& Van Gieson
Haversian Systems
- also called osteons
- Volkmann's canals
Lamellae
- concentric
- interstitial
- circumferential
Cells
- osteocytes
- canaliculi
Bone Cells
Osteocytes
- mature bone-forming cells embedded in bone matrix
- derive from osteogenic stem cells forming Osteoblasts
- line surface of bone, secrete organic matrix of bone (osteoid), converted into osteocytes when become embedded in matrix (which calcifies soon after deposition) (Google- osteoblast images)
Osteoclasts
- bone-resorbing multinucleated macrophage-like cells, seal a small segment of extracellular space (between plasma membrane and bone surface), HCl secreted into this space by osteoclasts dissolves calcium phosphate crystals (give bone rigidity and strength) (Google- osteoclast images)
- do not mistake for megakaryocytes, found in bone marrow not associated with bone matrix.
Bone Matrix
The bone matrix has 2 major components. Organic portion composed of mainly collagen Type 1 (about 95%) and amorphous ground substance. Inorganic portion (50% dry weight of the matrix) composed of hydroxyapatite crystals, calcium, phosphorus, bicarbonate, nitrate, Mg, K, Na. (Google- bone matrix images)
Links
- Original class notes
- UNSW Virtual Slidebox Virtual Slidebox Phase 1
- Virtual Slidebox of Histology (USA) Skeletal system
Other Textbooks
- Anatomy of the Human Body (H. Gray, 1918.) historical anatomy text Osteology
- Molecular Biology of the Cell Bone Is Continually Remodeled by the Cells Within ItImage: Figure 22-52. Deposition of bone matrix by osteoblasts.Image: Figure 22-56. The development of a long bone.
- Molecular Cell Biology Mutations in Collagen Reveal Aspects of Its Structure and Biosynthesis
- The Cell- A Molecular Approach Steroid Hormones and the Steroid Receptor Superfamily
- Clinical Methods: The History, Physical, and Laboratory Examinations 100. Alkaline Phosphatase and Gamma Glutamyltransferase
- Endocrinology: An Integrated Approach by Nussey, S.S. and Whitehead, S.A. Endocrinology: Definition and causes of osteoporosis
- Developmental Biology 6th ed. by Gilbert, Scott F. Aging: The Biology of Senescence
