BGDA Practical Placenta - Villi Development: Difference between revisions
No edit summary |
|||
Line 56: | Line 56: | ||
[[File:Placenta_and_explant_model.jpg|thumb|600px|Placental villi cartoon]] | [[File:Placenta_and_explant_model.jpg|thumb|600px|Placental villi cartoon]] | ||
==Cytotrophoblast Layer== | ==Additional Information== | ||
===Cytotrophoblast Layer=== | |||
There is a new interpretation of the changes that are occuring in the cytotrophoblast (CTB) layer during early to full-term human placenta development. Traditionally the interpretation was that the cytotrophoblast layer thinned and became discontinuous towards term. The thinning is thought due to the epithelium surface expanding at a faster rate than its volume. Two recent studies suggest that while the cytotrophoblast layer does indeed thin, it does not become discontinuous. | There is a new interpretation of the changes that are occuring in the cytotrophoblast (CTB) layer during early to full-term human placenta development. Traditionally the interpretation was that the cytotrophoblast layer thinned and became discontinuous towards term. The thinning is thought due to the epithelium surface expanding at a faster rate than its volume. Two recent studies suggest that while the cytotrophoblast layer does indeed thin, it does not become discontinuous. | ||
==Syncytiotrophoblast Layer== | ===Syncytiotrophoblast Layer=== | ||
The syncytiotrophoblast (STB) layer forms the epithelial covering of the entire villous tree. These cells are multinucleated, terminally-differentiated syncytium formed by the fusion of the underlying progenitor cytotrophoblast (CTB) cells. The process is described as "syncytialization" and is mediated by syncytin-1, an envelope protein of a human endogenous retrovirus W (HERV-W). The differentiation is regulated by chorionic gonadotropin (hCG) and the fusion of cytotrophoblast cells is ongoing during placental development. | The syncytiotrophoblast (STB) layer forms the epithelial covering of the entire villous tree. These cells are multinucleated, terminally-differentiated syncytium formed by the fusion of the underlying progenitor cytotrophoblast (CTB) cells. The process is described as "syncytialization" and is mediated by syncytin-1, an envelope protein of a human endogenous retrovirus W (HERV-W). The differentiation is regulated by chorionic gonadotropin (hCG) and the fusion of cytotrophoblast cells is ongoing during placental development. | ||
Line 68: | Line 70: | ||
Studies have suggested that these cells are transcriptionally inactive. A recent study using a number of different detection techniques now suggests that at least some of the cells nuclei may still be transcriptionally inactive. | Studies have suggested that these cells are transcriptionally inactive. A recent study using a number of different detection techniques now suggests that at least some of the cells nuclei may still be transcriptionally inactive. | ||
==Mesenchymal Villi== | ===Mesenchymal Villi=== | ||
Mesenchymal villi generate all other villous types: | Mesenchymal villi generate all other villous types: | ||
* immature intermediate villi | * immature intermediate villi |
Revision as of 13:06, 4 June 2012
Practical 14: Implantation and Early Placentation | Villi Development | Maternal Decidua | Cord Development | Placental Functions | Diagnostic Techniques | Abnormalities |
Chorionic Villi
- stem villi - or anchoring villi, cytotrophoblast cells attached to maternal tissue.
- branched villi - or terminal villi, grow from sides of stem villi, region of main exchange, surrounded by maternal blood in intervillous spaces.
First trimester and term chorionic villi
Virtual Slide
We will now look at an example of first trimester placentation in a Virtual Slide. Please note that there are additional slides listed in the current set, only the first will be covered in the practical class.
Chorionoic Villi Location
Originally villi cover entire chorionic surface and then become restricted to decidua basalis region forming 2 regions:
- Frondosum - "leafy" where villi are mainly located.
- Capsularis - smooth chorion, where villi are absent or not abundant.
Additional Information
Cytotrophoblast Layer
There is a new interpretation of the changes that are occuring in the cytotrophoblast (CTB) layer during early to full-term human placenta development. Traditionally the interpretation was that the cytotrophoblast layer thinned and became discontinuous towards term. The thinning is thought due to the epithelium surface expanding at a faster rate than its volume. Two recent studies suggest that while the cytotrophoblast layer does indeed thin, it does not become discontinuous.
Syncytiotrophoblast Layer
The syncytiotrophoblast (STB) layer forms the epithelial covering of the entire villous tree. These cells are multinucleated, terminally-differentiated syncytium formed by the fusion of the underlying progenitor cytotrophoblast (CTB) cells. The process is described as "syncytialization" and is mediated by syncytin-1, an envelope protein of a human endogenous retrovirus W (HERV-W). The differentiation is regulated by chorionic gonadotropin (hCG) and the fusion of cytotrophoblast cells is ongoing during placental development.
Cellular parts derived from the syncytiotrophoblasts (apoptotic nuclei and microparticulate debris) can be shed into the maternal blood in which they are bathed. The apototic process appears to be part of the fusion mechanism between cytotrophoblast and the overlying multinucleate syncytiotrophoblast layer.
Studies have suggested that these cells are transcriptionally inactive. A recent study using a number of different detection techniques now suggests that at least some of the cells nuclei may still be transcriptionally inactive.
Mesenchymal Villi
Mesenchymal villi generate all other villous types:
- immature intermediate villi
- stem villi
- mature intermediate villi
- terminal villi
Mesenchymal villi continuously form out of the trophoblastic sprouts throughout pregnancy and have been considered the basis for growth and differentiation of the villous trees.
- Gray0034.gif
Terms
Practical 14: Implantation and Early Placentation | Villi Development | Maternal Decidua | Cord Development | Placental Functions | Diagnostic Techniques | Abnormalities |