Aschheim-Zondek Test 1928 Movie

Embryology - 10 Dec 2023 Expand to Translate
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<html5media height="650" width="450">File:Aschheim-Zondek Test 1928.mp4</html5media>

This animation shows the basis of the historic 1928 Aschheim-Zondek Pregnancy Test.

The basis of the original historic Aschheim-Zondek^[1] test developed in 1928 was to identify the changes in immature female mouse genital system induced by female human urine injected subcutaneously into these immature mice. These changes could be seen by carrying out histology on the mouse ovary to detect follicle development.

If the woman was pregnant - the presence of hormones (hCG) induced changes in the mouse genital tract physiologically similar to those produced by sex hormones.
- follicle maturation, corpora heamorrhagicum and corpora lutea formation.
If the woman was not pregnant - there were no changes induced.
- only primordial, preantral and antral follicles present.

This early mouse test was later replaced with a similar, but simpler, urine test using either the frog (Xenopus) or rabbit animal models.

Modern home tests use a simple one step urine sample detecting the presence of the hormone human Chorionic Gonadotropin (hCG). Animation based upon original line drawings.^[2]

Reference

↑ Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).
↑ Ettinger GH, Smith GL & McHenry EW. (1931). THE DIAGNOSIS OF PREGNANCY WITH THE ASCHHEIM-ZONDEK TEST. Can Med Assoc J , 24, 491-5. PMID: 20318243

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Cite this page: Hill, M.A. (2023, December 10) Embryology Aschheim-Zondek Test 1928 Movie. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/Aschheim-Zondek_Test_1928_Movie

What Links Here?

[1] Aschheim, S., and Zondek, B., Klin. Wschr., 7 8, 1401 (1928).

[PMID20318243-2] Ettinger GH, Smith GL & McHenry EW. (1931). THE DIAGNOSIS OF PREGNANCY WITH THE ASCHHEIM-ZONDEK TEST. Can Med Assoc J , 24, 491-5. PMID: 20318243

[1]

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