ANAT2341 Lab 8: Difference between revisions

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'''PRACTICAL CLASS PROGRAM:'''
* Weekly Quiz + revision (10 minutes)
* Completion of surveys (10 minutes)
* Practical class activities (40 minutes)
* Guest Lecture by A/Prof Stuart Fraser (45 minutes)
* Practical Class Revision (15 minutes)




== 1. QUIZ ==
'''PRACTICAL CLASS ACTIVITIES''' (40 minutes):
* Cell lineage activity
* Investigate the chicken embryo skeletal preps


== 2. Guest Lecturer - Sally Dunwoodie ==
{|
| width=185px|[[File:Sally.jpeg|180px]]


'''LEARNING OBJECTIVES''':
* Understanding organogenesis
* Understanding the developmental paths of cell types/structures
* Understand the developmental basis of human disease
* Understanding skeletal development
* Understanding blood cell development
* Understanding research into blood cell development


| valign=top|'''Somitogenesis and Congenital Vertebral Malformation'''
 
 
'''Blood Cell Development - A/Prof Stuart Fraser'''
<br><br>
<br><br>
Professor Sally Dunwoodie is an internationally renowned biomedical researcher at the Victor Chang Cardiac Research Institute. She has dedicated her life’s work to understanding how babies develop and to finding out why some 3-6% have birth defects. Some 4.9 million babies are born with a serious birth defect around the globe every year.
Biographical details
 
Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan.
Back to Top


Professor Dunwoodie established and leads the Chain Reaction Program in Congenital Heart Disease, the largest Australian genome sequencing initiative in congenital heart disease. The program is discovering the genetic causes of heart defects family by family, with the promise that genetic diagnosis of birth defects will become a routine part of clinical practice.
Stuart's main research interests focus upon the mechanisms controlling the formation of the {{blood}}, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.


Professor Dunwoodie is also a world leader in identifying causes of vertebral defects, having discovered six of the seven genes known to cause such defects.
==References==
{{#pmid:31273739}}


Professor Dunwoodie’s discoveries have already changed clinical practices and have led to genetic diagnostic tests being available worldwide. In 2017 Professor Dunwoodie’s team revealed a double breakthrough that has the potential to prevent some cases of recurrent miscarriage and multiple types of birth defects.
{{#pmid:29076088}}


They discovered that deficiency in NAD, a vital molecule that is required for hundreds of activities in all cells, causes recurrent miscarriage and multiple types of birth defects in humans and mice. These defects were completely prevented with supplementation of niacin (vitamin B3) during pregnancy in mice. These discoveries from the Victor Chang Cardiac Research Institute are believed to be amongst Australia’s greatest ever in pregnancy research.
{{#pmid:28401096}}


{{#pmid:28395744}}


[https://www.victorchang.edu.au/heart-research/embryology VCCRI - Embryology]
{{#pmid:26898901}}
|}


{{#pmid:26113865}}


{{2018ANAT2341}}
Search PubMed: [https://www.ncbi.nlm.nih.gov/pubmed/?term=Fraser%20ST%5BAuthor%5D&cauthor=true&cauthor_uid=31273739 Fraser ST]

Latest revision as of 16:37, 8 November 2019

PRACTICAL CLASS PROGRAM:

  • Weekly Quiz + revision (10 minutes)
  • Completion of surveys (10 minutes)
  • Practical class activities (40 minutes)
  • Guest Lecture by A/Prof Stuart Fraser (45 minutes)
  • Practical Class Revision (15 minutes)


PRACTICAL CLASS ACTIVITIES (40 minutes):

  • Cell lineage activity
  • Investigate the chicken embryo skeletal preps


LEARNING OBJECTIVES:

  • Understanding organogenesis
  • Understanding the developmental paths of cell types/structures
  • Understand the developmental basis of human disease
  • Understanding skeletal development
  • Understanding blood cell development
  • Understanding research into blood cell development


Blood Cell Development - A/Prof Stuart Fraser

Biographical details

Stuart Fraser joined the Discipline of Physiology as Sesquicentenial lecturer in Molecular Embryology in April 2010. Prior to returning to Australia, Dr. Fraser was Assistant Professor in Hematology/Medical Oncology in the Mount Sinai School of Medicine in New York City for 6 years. Dr. Fraser also completed postdoctoral studies at the University of Mainz in Germany and spent 4 years at Kyoto University in Japan. Back to Top

Stuart's main research interests focus upon the mechanisms controlling the formation of the blood, or hematopoietic lineages, in the embryo and how these processes can go awry in the adult.

References

Colonne CK, Yeo JH, McKenzie CV & Fraser ST. (2019). Identification and Analysis of Mouse Erythroid Progenitor Cells. Methods Mol. Biol. , 2029, 125-145. PMID: 31273739 DOI.

Yeo JH, Cosgriff MP & Fraser ST. (2018). Analyzing the Formation, Morphology, and Integrity of Erythroblastic Islands. Methods Mol. Biol. , 1698, 133-152. PMID: 29076088 DOI.

Yumine A, Fraser ST & Sugiyama D. (2017). Regulation of the embryonic erythropoietic niche: a future perspective. Blood Res , 52, 10-17. PMID: 28401096 DOI.

Ross SB, Fraser ST, Bagnall RD & Semsarian C. (2017). Peripheral blood derived induced pluripotent stem cells (iPSCs) from a female with familial hypertrophic cardiomyopathy. Stem Cell Res , 20, 76-79. PMID: 28395744 DOI.

Yeo JH, McAllan BM & Fraser ST. (2016). Scanning Electron Microscopy Reveals Two Distinct Classes of Erythroblastic Island Isolated from Adult Mammalian Bone Marrow. Microsc. Microanal. , 22, 368-78. PMID: 26898901 DOI.

Al-Drees MA, Yeo JH, Boumelhem BB, Antas VI, Brigden KW, Colonne CK & Fraser ST. (2015). Making Blood: The Haematopoietic Niche throughout Ontogeny. Stem Cells Int , 2015, 571893. PMID: 26113865 DOI.

Search PubMed: Fraser ST