2016 Group Project 1: Difference between revisions
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===The signalling pathways:=== | ===The signalling pathways:=== | ||
*Canonical Pathway - Gloria | *Canonical Pathway - Gloria | ||
• The Wnt family of secreted glycolipoproteins play an important role in the role of embryonic development and adult homeostasis. | |||
• They do so via the transcription of β-catenin, which accumulates in the cytoplasm and eventually gets translocated into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. | |||
• The canonical Wnt pathway of (Wnt/ β-catenin pathway) is the Wnt pathway that causes β-catenin to stay in the cytoplasm rather than be degraded through ubiquitination which is induced by destruction complexes. The destruction complexes which sends β-catenin to proteasome for digestion are proteins such as: Axin, adenomatosis, polyposiscoli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). | |||
• Once the stabilised β-catenin enters the cell nucleus it acts as a transcriptional coactivator for transcription of Wnt-target genes. The primary family of transcription factor which β-catenin associates with is the TCF/LEF family. Activation through β-catenin is mediated with compounds such as histone acetyl transferase CBP, the chromatin-remodeling SWI/SNF complex and Bcl9 bound to pygopus (Pyg). | |||
• This signalling pathway is crucial for deciding the fate of cells during early embryogenesis. | |||
*Non-Canonical Pathway - Caroline | *Non-Canonical Pathway - Caroline | ||
*WnT-Calcium Ion Pathway - Tony | *WnT-Calcium Ion Pathway - Tony | ||
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What can go wrong? | What can go wrong? | ||
==Wnt-Calcium Ion Pathway== | ==Wnt-Calcium Ion Pathway== |
Revision as of 08:54, 2 September 2016
2016 Student Projects | ||||
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Signalling: 1 Wnt | 2 Notch | 3 FGF Receptor | 4 Hedgehog | 5 T-box | 6 TGF-Beta | ||||
2016 Group Project Topic - Signaling in Development
OK you are now in a group, add a topic with your student signature to the group page. | ||||
This page is an undergraduate science embryology student project and may contain inaccuracies in either descriptions or acknowledgements. |
Group Assessment Criteria |
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Science Student Projects
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More Information on Assessment Criteria | Science Student Projects |
Topic: WnT Signaling Pathway in skin of fetus
The signalling pathways:
- Canonical Pathway - Gloria
• The Wnt family of secreted glycolipoproteins play an important role in the role of embryonic development and adult homeostasis. • They do so via the transcription of β-catenin, which accumulates in the cytoplasm and eventually gets translocated into the nucleus to act as a transcriptional coactivator of transcription factors that belong to the TCF/LEF family. • The canonical Wnt pathway of (Wnt/ β-catenin pathway) is the Wnt pathway that causes β-catenin to stay in the cytoplasm rather than be degraded through ubiquitination which is induced by destruction complexes. The destruction complexes which sends β-catenin to proteasome for digestion are proteins such as: Axin, adenomatosis, polyposiscoli (APC), protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). • Once the stabilised β-catenin enters the cell nucleus it acts as a transcriptional coactivator for transcription of Wnt-target genes. The primary family of transcription factor which β-catenin associates with is the TCF/LEF family. Activation through β-catenin is mediated with compounds such as histone acetyl transferase CBP, the chromatin-remodeling SWI/SNF complex and Bcl9 bound to pygopus (Pyg). • This signalling pathway is crucial for deciding the fate of cells during early embryogenesis.
- Non-Canonical Pathway - Caroline
- WnT-Calcium Ion Pathway - Tony
How does it work in a foetus (skin formation) - Arsalan
What can go wrong?
Wnt-Calcium Ion Pathway
References
PMID 21903638