2014 Group Project 5

From Embryology
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2014 Student Projects
2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8
The Group assessment for 2014 will be an online project on Fetal Development of a specific System.

This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements.

Cardiovascular

--Mark Hill (talk) 15:16, 26 August 2014 (EST) OK you have some headings, how about some content, references, sources for each section. See Lab 3 Assessment.

Introduction

  • The cardiovascular system is one of the first systems to function within the embryo
  • The heart begins to function during the 4th week

[Textbook- Larsen's Human Embryology, 4th ed.]

Timeline

[1] [2] [3] [4] [5] [6]

  1. <pubmed>12807866</pubmed>
  2. <pubmed>12860885</pubmed>
  3. <pubmed>14506305</pubmed>
  4. <pubmed>20712587</pubmed>
  5. <pubmed>22679138</pubmed>
  6. <pubmed>21367775</pubmed>

--Z3418340 (talk) 00:21, 27 August 2014 (EST)

File:Development of the fetal heart.jpeg


(From Textbook- Larsen's Human Embryology, 4th ed. - http://www.mdconsult.com.wwwproxy0.library.unsw.edu.au/books/page.do?eid=4-u1.0-B978-0-443-06811-9..10012-0&isbn=978-0-443-06811-9&uniqId=462162262-2#4-u1.0-B978-0-443-06811-9..10012-0--fig42)

Primordial heart tube

  • Arises predominantly from splanchnic mesoderm in the cardiogenic region
  • Initially bilateral, the cardiogenic region cranially merges to form a horseshoe
  • During the third week (Approximately day 18), angioblastic chords develop in the cardiogenic mesoderm. It forms the bilateral endocardial heart tubes
  • Lateral folding of the embryo brings the heart tubes into the ventral midline.
  • Fusion of the heart begins cranially and extends caudally.
  • Certain dilations appear in the heart tube including:
    • Truncus arteriosus
    • Bulbus cordis
    • Primordial ventricle
    • Primordial atrium
    • Sinus venosus (further divided into right horn and left horn)


Heart tube looping

  • Most looping occurs in the fourth week of development and is completed by the fifth.
  • The straight heart tube begins to elongate, most notably with growth in the bulbus cordis and primitive ventricle.
  • This causes the heart to bend ventrally and rotate to the right- this forms a C-shaped loop.
  • The ventricular bend moves caudally. The distance between outflow and inflow tracts diminishes
  • The inflow (atrial) and outflow tracts converge. Myocardial cells are added forming the truncus arteriosus.

Atrial ventricular septation

Outflow tract

Heart valves

Vascular overview

Current Research

[1] [2] [3] [4] [5]

  1. <pubmed>25015802</pubmed>
  2. <pubmed>24910745</pubmed>
  3. <pubmed>24520485</pubmed>
  4. <pubmed>24855117</pubmed>
  5. <pubmed> 23723064</pubmed>

Historic Findings

[1] [2] https://www.youtube.com/watch?v=WXLPxjJszio

  1. <pubmed>3058502</pubmed>
  2. <pubmed>19184179</pubmed>

--Z3418340 (talk) 00:21, 27 August 2014 (EST)

Abnormalities

Atrial Septal Defect

Ventricular Septal Defect

Atrioventricular Septal Defect

[1]

  1. <pubmed>22709652</pubmed>

Double Outlet Right Ventricle

Transposition of the Great Arteries

Patent Ductus Arteriosus

Tetralogy of Fallot

Hypoplastic Left Heart Syndrome

[1] [2] [3]

  1. <pubmed>23723064</pubmed>
  2. <pubmed>10222336</pubmed>
  3. <pubmed>22595346</pubmed>