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- 01:46, 19 November 2010 S8600021 talk contribs uploaded File:Trisomy 21 detection using tandem single nucleotide polymorphisms.jpg (==Prenatal Detection of Trisomy 21 Using Tandem Single Nucleotide Polymorphisms== DNA obtained from maternal buccal swab represent maternal germinal DNA. Tandem SNP sequences on chromosome 21 are amplified by MLA followed by High-Fidelity PCR (HiFi PCR) )