File:Lymph node - high endothelial venule.jpg

Lymph Node - High Endothelial Venule

Chemokines and chemokine-binding molecules expressed in and around high endothelial venules (HEVs) in a concentric manner might function coordinately in lymphocyte trafficking across HEVs. We propose that several chemokine-binding molecules are expressed in a concentric manner in HEVs and their surrounds. The coordinated actions of chemokines and chemokine-binding molecules in and around HEVs are shown schematically in sequential order. a | In the lumen of HEVs, heparan sulphate proteoglycans (red) can capture and present a lymphoid chemokine (X, green) in situ. Duffy antigen receptor for chemokines (DARC; black) — a non-signalling chemokine receptor — captures and scavenges inflammatory chemokines, such as CXC-chemokine ligand 1 (CXCL1; pink), which is constitutively produced by HEVs. b | In the basal lamina of HEVs, another chemokine-binding protein MAC25 (dark blue) can capture a chemokine, such as CC-chemokine ligand 21 (CCL21), CXCL10 or CCL5 (Y, light blue). In addition, other components in the basal lamina such as collagen and fibronectin (grey) can capture a different chemokine (Z, yellow) expressed in the HEV area. c | When lymphocytes rolling along the HEV endothelium recognize chemokine X presented in the lumen, they are signalled to activate their integrins and firmly adhere to HEVs. d | Subsequently, some of the adhering lymphocytes migrate across HEVs and are stimulated by chemokine Y, which is immobilized on MAC25. e | Farther outside, other chemokine-binding molecules, such as collagen IV and fibronectin, can capture a different chemokine (Z). Some of the extravasating lymphocytes might interact with chemokine Z and be stimulated to move into this area. f | By sequentially recognizing the multiple chemokines presented on the tissue matrix, more and more lymphocytes extravasate and progressively move from the inside to the outside of HEVs.

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Reference

<pubmed>15122201</pubmed>| Nat Rev Immunol.

Adapted by permission from Macmillan Publishers Ltd: Nat. Rev. Immunol.: 2004, 4(5);360-70, copyright (2004)

Licensee: Mark A Hill License Number: 2857291045727 Publication: Nature Reviews Immunology

Title: Lymphocyte trafficking across high endothelial venules: dogmas and enigmas Type Of Use: post on the internet

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