File:TGF-beta signaling pathway.jpg
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Basic overview of TGF-β signalling pathway
Binding of a ligand to a Type II receptor initiates signaling. The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). Together with the Co-Smad (Smad4), this complex enters the nucleus and activates the transcription of target genes. The pathway can be inhibited by extracelluar antagonists, or intracellularly via Inhibitor-Smad (Smad6/7) or the ubiquitin ligase SMURF.
Original file name: Figure 1. Journal.pone.0024152.g001.jpg dpi:10.1371/journal.pone.0024152.g001
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Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan
| Gwalagizhi | Nyangagi | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 14:11, 10 September 2011 | | 600 × 559 (47 KB) | S8600021 (talk | contribs) | ==Basic overview of TGF-β signalling pathway== Binding of a ligand to a Type II receptor initiates signaling. The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). Together with the Co-Smad (Smad4), this |
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