File:Human female fibroblast line (47,XXX) XIST expression.jpg

X Inactivation

XIST expression in two cell nuclei using RNA FISH probes for the human XIST RNA (green) in the human female fibroblast line GM04626 (karyotype: 47,XXX). As there are 3 copies of the X chromosome in each cell, there are 2 inactive X chromosomes as shown by Xist staining.

doi:10.1371/journal.pone.0010787.g001

Original file name: Figure 1. journal.pone.0010787.g001.jpg (Image extracted from panel C of the complete original figure and slightly increased in size)

Reference

<pubmed>20520737</pubmed>| PLoS One

Citation: Thorogood NP, Brown CJ (2010) Active Chromatin Marks Are Retained on X Chromosomes Lacking Gene or Repeat Silencing Despite XIST/Xist Expression in Somatic Cell Hybrids. PLoS ONE 5(5): e10787. doi:10.1371/journal.pone.0010787

Copyright: © 2010 Thorogood, Brown. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.