File:Mouse-kidney in vitro.jpg
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Mouse wild-type kidneys in organ culture
Kidneys of wild-type (A) and mutant genotypes (B–D), carrying Hoxb7/myrVenus, were excised at E12.5, cultured in vitro, and photographed at the indicated times. The Ret−/− Wolffian duct (B) failed to develop a ureter or kidney, while the Spry1−/− kidney (C) has multiple ureters (arrowheads), swollen UB tips and an enlarged common nephric duct (cnd). (D), in two examples of Gdnf−/−;Spry1−/− mutant kidneys, UB branching is retarded at E12.5, and subsequent branching in culture displays abnormal patterns (asterisks and arrowheads – see text) compared to wild-type.
Original file name: Figure 4. doi:10.1371/journal.pgen.1000809.g004
Reference
<pubmed>20084103</pubmed>| PLoS Genet.
Copyright: © 2010 Michos et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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| current | 19:24, 24 September 2010 | | 955 × 461 (57 KB) | S8600021 (talk | contribs) | ==Mouse wild-type kidneys in organ culture== Kidneys of wild-type (A) and mutant genotypes (B–D), carrying Hoxb7/myrVenus, were excised at E12.5, cultured in vitro, and photographed at the indicated times. The Ret−/− Wolffian duct (B) failed to de |
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