Template:Second-generation BTKi table
From Embryology
BTK inhibitor | BTK binding mechanism | Selectivity for BTK | Relevant non-BTK targets | Phase of clinical development |
---|---|---|---|---|
Acalabrutinib | Covalent, irreversible | High | N/A | II/III |
Zanubrutinib | Covalent, irreversible | Moderate | N/A | II/III |
Tirabrutinib | Covalent, irreversible | High | N/A | I/II |
Vecabrutinib | Non-covalent, reversible | Moderate | interleukin-2-inducible (ITK) | I/II |
LOXO-305 | Non-covalent, reversible | High | N/A | I |
ARQ-531 | Non-covalent, reversible | Low | Lck/Yes novel tyrosine kinase (LYN), mitogen-activated protein kinase kinase 1 (MEK1) | I |
Table data [1] |