File:Mouse - stomach 01.png

Morphological abnormality in the stomach of Sfrp1−/− Sfrp2−/− and Sfrp1−/− Sfrp2−/− Sfrp5+/− embryos

E13.5

(A–E) A small fore-stomach is formed in Sfrp1−/− Sfrp2−/− and Sfrp1−/− Sfrp2−/− Sfrp5+/− embryos at E13.5, as evidenced by expression of Shh (A), Pitx1 (B), Nkx6.3 (C), Islet1 (D) and Barx1 (E). A broken line depicts Shh-negative epithelium along the greater curvature. Curved arrows, an arrow and double arrowheads denote the fore-stomach, the junction of the esophagus and fore-stomach and the pyloric sphincter, respectively. A white arrowhead defines the caudal end of the fore-stomach. A black arrowhead indicates the rostral end of marker gene expression. Fs, fore-stomach.

Scale bar: 500 µm.

E10.5

(F–I) A region of presumptive stomach and duodenum is generated normally in Sfrp1−/− Sfrp2−/− and Sfrp1−/− Sfrp2−/− Sfrp5+/− embryos at E10.5, which is suggested by the expression patterns of Shh (F), Pdx1 (G), Sfrp5 (H) and Barx1 (I). The area between the arrowheads identifies a Shh-negative region in the gut epithelium (F). Arrows depict the rostral and caudal ends of marker gene expression (G, H). Ce, cecum; Lb, lung bud; Pb, pancreatic bud; St, stomach.

Scale bar: 500 µm.

Original Image: Figure 1. Journal.pgen.1000427.g001.png

http://www.plosgenetics.org/article/slideshow.action?uri=info:doi/10.1371/journal.pgen.1000427&imageURI=info:doi/10.1371/journal.pgen.1000427.g001

Reference

<pubmed>19300477</pubmed>| PLoS Genet.