File:Blood-brain barrier EM01.jpg

FIGURE 11 Regions of overlap between neighboring endothelial cells, illustrating range of variation in structure of the intercellular cleft. In Fig. 11, the cleft is obliterated by a tight junction (arrow) extending throughout most of its length. The region of the intercellular cleft indicated by the arrow in Fig. 11 is shown in inset at higher magnification to illustrate that the total width of the tight junc- tion (between arrows at right) is less than twice the width of the adjacent plasma mem- brane (between arrows at left). Normal mouse; uranyl acetate block stain. Fig. 11, X 170,000. Fig. 11 inset, X 420,000.

FIGURE 12 Astrocytic end feet (A) lying between a myclinated axon and the basement lamina of the vascular endothelium. A cleft between the astrocytic end feet extends from the basement lamina to a perivascular myelinated axon and appears open except near the blood vessel where it is invaded by some basement lamina material.

Normal mouse; uranyl acetate block stain. X 150,000.

Reference

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