File:Age-related chromosome segregation errors during MI model.jpg
![File:Age-related chromosome segregation errors during MI model.jpg](/embryology/images/thumb/6/6a/Age-related_chromosome_segregation_errors_during_MI_model.jpg/680px-Age-related_chromosome_segregation_errors_during_MI_model.jpg?20150704011113)
Original file (900 × 794 pixels, file size: 112 KB, MIME type: image/jpeg)
Bivalents with weakened cohesion in aged oocytes undergo hyperstretching and separation into univalents by microtubule-mediated bipolar spindle forces.
This bipolar forces in turn biorient the sister kinetochores (KTs) of the univalents. The univalents are therefore strongly biased towards predivision of sister chromatids, including balanced predivision. After balanced predivision during MI, the chromatids undergo random segregation during MII.
- Links: Oocyte Development | Meiosis | Trisomy 21
Reference
<pubmed>26130582</pubmed>| Nat Commun.]
Copyright
This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Figure 5 altered in size and labelling. Above text from figure legend.
Cite this page: Hill, M.A. (2024, June 26) Embryology Age-related chromosome segregation errors during MI model.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Age-related_chromosome_segregation_errors_during_MI_model.jpg
- © Dr Mark Hill 2024, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G
File history
Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan
Gwalagizhi | Nyangagi | Dimensions | User | Comment | |
---|---|---|---|---|---|
current | 11:11, 4 July 2015 | ![]() | 900 × 794 (112 KB) | Z8600021 (talk | contribs) | Premature bivalent separation into univalents precedes age-related chromosome segregation errors during MI. Bivalents with weakened cohesion in aged oocytes undergo hyperstretching and separation into univalents by microtubule-mediated bipolar spindl... |
You cannot overwrite this file.
File usage
The following 3 pages use this file: