File:Intraepithelial lymphocyte differentiation 01.jpg
Original file (1,200 × 585 pixels, file size: 108 KB, MIME type: image/jpeg)
Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes
IELs - intraepithelial lymphocytes
In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens. In addition, the precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery. These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment. APC, antigen-presenting cell; MLNs, mesenteric lymph nodes.
Figure 1. Nihms307956-23.jpg
File history
Yi efo/eka'e gwa ebo wo le nyangagi wuncin ye kamina wunga tinya nan
| Gwalagizhi | Nyangagi | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 13:54, 26 Ocak 2015 | | 1,200 × 585 (108 KB) | Z8600021 (talk | contribs) | ==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== IELs - intraepithelial lymphocytes In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection an... |
You cannot overwrite this file.
File usage
The following page uses this file:
