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Adipocyte Differentiation Regulation
Zfp521 is novel modulator of adipocyte commitment and differentiation.
Many transcription factors are induced during adipocyte differentiation. Some of these, like members of the AP-1 family, are induced early during adipocyte development. Other transcription factors like PPARγ promote adipocyte differentiation. Adipocyte development is also influenced by several transcription factor families that have negative effectors on adipogenesis. Zfp521 is a novel modulator of adipocyte development that mediates its inhibitory effects on adipocyte development by regulating the activity of two other transcription factors, Zfp423 and Ebf1.
Reference
<pubmed>23209380</pubmed>| PMC3507952 | PLoS Biol.
Copyright
© 2012 Jacqueline M. Stephens. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Figure 1. Journal.pbio.1001436.g001.jpg doi:10.1371/journal.pbio.1001436.g001
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