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- 15:11, 10 September 2011 S8600021 talk contribs uploaded File:TGF-beta signaling pathway.jpg (==Basic overview of TGF-β signalling pathway== Binding of a ligand to a Type II receptor initiates signaling. The sequestering of a Type I receptor results in the activation of a Receptor-Smad (Smad1/5, Smad2/3). Together with the Co-Smad (Smad4), this )