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- 10:57, 18 August 2011 Z3391078 talk contribs uploaded File:PULMONARY HYPERTENSION.JPG (This flow chart demonstrates the complex pathophysiology of pulmonary hypertension in thalassemia. Increased cardiac output and diastolic dysfunction cause abnormal loading of the pulmonary artery. Lung disease can exacerbate night-time hypoxia, a powerfu)