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- 23:31, 16 August 2011 Z3293267 talk contribs uploaded File:Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones.jpg (==Chromosome segregation defects associated with abnormal spindles in UBE3A shRNA knockdown clones== Examples of cells attempting to divide with missegregated (clone T, anaphase) and lagging chromosomes (clone U, telophase) (arrows). Also note cells with)