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- 12:04, 17 February 2011 S8600021 talk contribs uploaded File:Model - TGF regulation of SHH.jpg (==Schematic diagram showing activation of TGF-β receptor by TGF-β1which leads to the up-regulation of Shh expression== The secreted Shh protein then activates Hh signaling pathway by inhibition of Patched (smoothened suppressor), which will repress smo)