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- 10:51, 26 Ocak 2010 S8600021 talk contribs uploaded File:Trisomy18male.jpg (Trisomy 18 (Edwards Syndrome) karyotype. First recognized as a specific clinical entity by the discovery of an extra chromosome 18 in babies with a particular pattern of malformation by three independent groups (Edwards et al., Patau et al., Smith et al.)