File:Tectum signaling model 01.jpg

Tectum Development Signaling Model

Model for a possible cooperation of Meis2, Pax3, Pax7 and Otx2during tectal development.

Red lines indicate negative regulation, green arrows positive regulation. Dashed lines indicate hypothetical direct regulation of the Meis2 promoter/enhancer by different Pax3 concentrations. Solid lines indicate indirect regulation of Meis2 expression via Pax3/7 mediated induction of Fgf8 as previously reported:

(1) Regulation of Meis2 expression in response to Ras-MAPK signaling levels reported in [19];

(2) Induction of Fgf8 by Pax3 and Pax7 reported in [11];

(3) Existence of Meis2-Otx2 containing protein complexes in the tectal anlage reported in [17].

Reference

<pubmed>22390724</pubmed>| BMC Dev Biol.

© 2012 Agoston et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Agoston et al. BMC Developmental Biology 2012 12:10 doi:10.1186/1471-213X-12-10

1471-213X-12-10-6.jpg