File talk:Bone marrow histology 01.jpg

The bone marrow vascular niche: home of HSC differentiation and mobilization

Physiology (Bethesda). 2005 Oct;20:349-56.

Kopp HG, Avecilla ST, Hooper AT, Rafii S. Source Weill Medical College of Cornell University, New York, New York, USA.

Abstract

The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis.

PMID 16174874

Full paper http://physiologyonline.physiology.org/content/20/5/349.full