File:Reticular network formation model.jpg

Model of Reticular Network Formation

1. Accumulation of lymphocytes induces alteration of mesenchymal progenitors such that they produce chemokines for further lymphocyte attraction and RF components via the secretion of TNFα or LTα (or related cytokines) and likely also via direct contacts mediated by adhesion molecules and LTα1β2.
2. Lymphocytes and differentiated FRCs gradually degrade preexisting matrix, and FRCs weave RF meshwork from the newly produced components.
3. Mature RN forms and antigen presentation occur on the stromal reticulum.

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