User talk:Z3439257

From Embryology
Revision as of 17:52, 15 October 2016 by Z3439257 (talk | contribs)

Wnt calcium ion signalling pathway

    • Regulation of cell adhesion, migration and tissue separation (mediated by CAMKII)
    • Inhibition of TCF/Beta-catenin signalling (mediated by calcineurin)
    • Ventral patterning (mediated by PKC)

Molecular Basis

1. Wnt-4, -5a & -11 are ligands identified to be able to activate wnt/calcium signalling pathway. wnt ligands binds to Fz receptors( more)

2.



were identified as ligands specifically activate this pathway. Wnt (5a) interact with Fz receptor. Fz receptor functions as a G-protein coupled receptor which activates Gaq/11. Gaq/11 further cleaves PIP2 into DAG and IP3. IP3 then interacts with the IP3R on the surface of endoplasmic reticulum and causes increase in intracellular calcium ions. Those calcium ions will then react with CAMKII or calcineurin leading to further internal effects. DAG and calcium ions are also able to activate proteins belongs to PKC family which also posses various cellular effects.


PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1.

Embryological events based on animal models

Xenopus

1. Gastrulation


  • Convergent extension (CE) movement in xenopus and vertebrae.

PMID 12729560 In xenopus explants, wnt-11 are expected to interact with Fz 7 and activates wnt/calcium signalling pathway.


Glossary

convergent extension

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