File:Zebrafish nephrogenesis signaling01.jpg
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Zebrafish Nephrogenesis Signaling
| Working model of etv5a and etv4 function in multiciliated cell (MCC) patterning during nephrogenesis. | Abbreviations |
|---|---|
| Interplay between retinoic acid (RA), etv5a, and Notch signaling in the renal progenitor field mediates multiciliated cell (MCC) formation during nephrogenesis.
etv5a responds downstream of RA signaling to promote MCC fate, although it is likely that etv5a is not the only target of RA in this pathway. Conversely, Notch signaling inhibits etv5a activity to restrict MCC formation and favor transportive cell identity. In addition, etv4 promotes MCC fate, although it is not resolved if etv4 acts within renal progenitors or neighboring tissues, and whether other known MCC specification factors impact etv4 in other embryonic locales to affect pronephros development. |
P (podocyte), N (neck), PCT (proximal convoluted tubule), PST (proximal straight tubule), DE (distal early), CS (corpuscle of Stannius), DL (distal late), PD (pronephric duct), C (cloaca). |
Reference
<pubmed>26827902</pubmed>
Copyright
https://creativecommons.org/licenses/by/4.0/
Fig. 7. 1-s2.0-S0012160615301068-gr7.jpg PMID and title added to original
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