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Introduction

Lymphatic system

While the structure of the lymphatic system (lympha = clear water) is well described, there is much to still learn about the complex development and function of this "system".

1. Immune - “monitor” of body surfaces, internal fluids
2. Extracellular fluid - returns interstitial fluid to circulation
3. Gastrointestinal tract - carries fat and fat-soluble vitamins

Aim

This lecture will provide an overview of the histology of key lymphoid organs, including the lymph nodes, spleen and thymus, as well as extranodal lymphoid tissues including mucosal associated lymphoid tissues (MALT)

Key Concepts

1. Lymphatic System
2. Organs - Thymus, Spleen
3. Lymph Nodes and Nodules
4. Bone Marrow
5. Extranodal Lymphoid Tissues
6. Mucosal Associated Lymphoid Tissues (MALT)

Textbook References

• SH Laboratory Support
• Janeway’s Immunobiology (see in additional information) NCBI Bookshelf
• Histology and Cell Biology - A.L. Kiersenbaum (2001) Chapter 6: Blood, Chapter 10: Immune-Lymphatic
• Previous Lectures: 2012 | 2010 | 2008

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Two Cellular Systems

• Lymphoid System - three major types of lymphocytes (T, B, and NK), tissues, organs and vessels

• Mononuclear Phagocytic System (MPS, also called Lymphoreticular System or Reticuloendothelial System, RES) - circulating monocytes of peripheral blood and non-circulating (fixed) tissue macrophages found throughout the body