File:Lymphatic vasculature 02.jpg
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Main steps of mammalian lymphatic vascular development
- Lymphatic endothelial cells (LECs) are specified in embryonic veins.
- LECs sprout toward Vegf-c–producing mesodermal cells and aggregate to form lymph sacs.
- Further sprouting produces the lymphatic primary plexus composed of capillary-like vessels. Myeloid cells produce cytokines and regulate lymphatic vascular morphogenesis.
- Primary plexus is further remodeled to form collecting, precollecting, and capillary compartments. Precollecting and collecting lymphatic vessels have intraluminal valves and basement membrane coverage. Collecting lymphatic vessels are surrounded by SMCs (red). (box) Genes important for collecting lymphatic vessel development.
Reference
<pubmed>21576390</pubmed>| PMC3166860 | J Cell Biol.
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© 2011 Schulte-Merker et al.
Above text modified from figure 2A legend.
The Rockefeller University Press, doi: 10.1083/jcb.201012094
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current | 15:05, 12 February 2013 | 1,280 × 454 (116 KB) | Z8600021 (talk | contribs) | ==Main steps of mammalian lymphatic vascular development== # LECs are specified in embryonic veins, from where they sprout toward Vegf-c–producing mesodermal cells and aggregate to form lymph sacs. # Further sprouting produces the lymphatic primary pl |
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