File:Lymph node structure 02.jpg: Difference between revisions

Lymph Node Structure

Schematic representation of the organization of a lymph node.

• Afferent lymphatics enter lymph nodes and deliver lymph to the subcapsular sinus (SCS), which forms a channel around the periphery of the lymph node.
• Lymphatic sinuses run from the SCS through the cortex to the medulla
• Efferent lymphatics exit the lymph node via efferent lymphatic vessels on the opposite (hilar) side of the organ.
• High endothelial venules (HEVs) - in the paracortex and cortical ridge, specialized vessels allow entry of leukocytes from the blood.
• Blood vessels enter and exit the lymph node on the hilar side, and snake through the lymph node like the branches of a tree.

• B cell follicles containing follicular dendritic cell (FDC) networks are arranged in the lymph node cortex and are separated from the SCS by a layer of marginal reticular cells (MRC).
• T cells zones in the paracortex, which contain many fibroblastic reticular cells (FRC), are separated by the cortical ridge, an area rich in T cells, dendritic cells (DCs), blood vessels, and FRC.

Scale bars represent 200 μM.

Lymph Node Cartoons: Detailed structure | Cartoon with Histology | Lymphocyte traffic | Simple structure | Simple node anatomy | Wiki node image | Internal structure | Mesenteric lymph node | Histology | Gallery | Lymph Node Development

Reference

Mueller SN & Germain RN. (2009). Stromal cell contributions to the homeostasis and functionality of the immune system. Nat. Rev. Immunol. , 9, 618-29. PMID: 19644499 DOI. Mueller

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Cite this page: Hill, M.A. (2026, March 7) Embryology Lymph node structure 02.jpg. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/File:Lymph_node_structure_02.jpg

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