User talk:Z3439257: Difference between revisions
| Line 10: | Line 10: | ||
===Molecular Basis=== | ===Molecular Basis=== | ||
1. Wnt-4, -5a & -11 are ligands identified to be able to activate wnt/calcium signalling pathway. wnt ligands binds to Fz receptors( more) | |||
2. PMID 24489854 | |||
beta-Arrastin 2 (Arrb2) binds with Dishevelled (Dvl) and the β and γ subunits of trimeric G-proteins, respectively Gβ and Gγ (Gβγ) to form a functional complex to conduct signal downwards from wnt fizzeld interaction. | |||
Arrb2 can also activate and induce translocation of PKC alpha to cell membrane. This activity is down stream of Fz7 activation. | |||
were identified as ligands specifically activate this pathway. Wnt (5a) interact with Fz receptor. Fz receptor functions as a G-protein coupled receptor which activates Gaq/11. Gaq/11 further cleaves PIP2 into DAG and IP3. IP3 then interacts with the IP3R on the surface of endoplasmic reticulum and causes increase in intracellular calcium ions. Those calcium ions will then react with CAMKII or calcineurin leading to further internal effects. DAG and calcium ions are also able to activate proteins belongs to PKC family which also posses various cellular effects. | |||
PMID 24489854 beta-Arrastin 2 (Arrb2) binds with Dishevelled (Dvl) and the β and γ subunits of trimeric G-proteins, respectively Gβ and Gγ (Gβγ) to form a functional complex to conduct signal downwards from wnt fizzeld interaction. | |||
PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1. | PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1. | ||
Revision as of 11:37, 11 October 2016
Wnt calcium ion signalling pathway
General introduction
- Ligands: Wnt-4, -5a & -11
- Downstream targets: CAMKII, calcineurin & PKC
- Main functions:
- Regulation of cell adhesion, migration and tissue separation (mediated by CAMKII)
- Inhibition of TCF/Beta-catenin signalling (mediated by calcineurin)
- Ventral patterning (mediated by PKC)
Molecular Basis
1. Wnt-4, -5a & -11 are ligands identified to be able to activate wnt/calcium signalling pathway. wnt ligands binds to Fz receptors( more)
2. PMID 24489854 beta-Arrastin 2 (Arrb2) binds with Dishevelled (Dvl) and the β and γ subunits of trimeric G-proteins, respectively Gβ and Gγ (Gβγ) to form a functional complex to conduct signal downwards from wnt fizzeld interaction. Arrb2 can also activate and induce translocation of PKC alpha to cell membrane. This activity is down stream of Fz7 activation.
were identified as ligands specifically activate this pathway. Wnt (5a) interact with Fz receptor. Fz receptor functions as a G-protein coupled receptor which activates Gaq/11. Gaq/11 further cleaves PIP2 into DAG and IP3. IP3 then interacts with the IP3R on the surface of endoplasmic reticulum and causes increase in intracellular calcium ions. Those calcium ions will then react with CAMKII or calcineurin leading to further internal effects. DAG and calcium ions are also able to activate proteins belongs to PKC family which also posses various cellular effects.
PMID 24489854 beta-Arrastin 2 (Arrb2) binds with Dishevelled (Dvl) and the β and γ subunits of trimeric G-proteins, respectively Gβ and Gγ (Gβγ) to form a functional complex to conduct signal downwards from wnt fizzeld interaction.
PMCID: PMC4342031 CAMKII physically interacts with DSH2. It is DSH2 which activates calcium ion pathway but not DSH1.
